Low high-density lipoprotein cholesterol is characterized by elevated oxidative stress

Karabacak M., VAROL E., KAHRAMAN F., ÖZAYDIN M., Türkdogan A. K., Ersoy I. H.

Angiology, vol.65, no.10, pp.927-931, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 10
  • Publication Date: 2014
  • Doi Number: 10.1177/0003319713512173
  • Journal Name: Angiology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.927-931
  • Keywords: high-density lipoprotein, oxidative stress, oxidative stress index
  • Kütahya Health Sciences University Affiliated: No

Abstract

High-density lipoprotein cholesterol (HDL-C) is an independent risk factor for premature atherosclerosis and cardiovascular disease. Plasma HDL exerts potent antioxidant activity. We evaluated parameters associated with oxidative stress in participants with low HDL-C. This study included 32 patients with low HDL-C (<35 mg/dL) and 33 age- and sex-matched control patients with normal HDL-C (>35 mg/dL). We evaluated clinical and laboratory parameters that are associated with oxidative stress. The oxidative stress index (OSI) levels were significantly higher in the low HDL-C group (3.32 [0.01-13.3] vs 0.74 [0.17-3.55] AU; P <.01) and negatively correlated with HDL-C levels. We suggest that change in OSI and uric acid levels in the study group might indicate increased oxidative status in patients with low HDL-C. This may be associated with increased cardiovascular risk.