Neuroprotective Effect of Resveratrol on Acute Brain Ischemia Reperfusion Injury by Measuring Annexin V, p53, Bcl-2 Levels in Rats

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KIZMAZOĞLU C., AYDIN H. E., SEVİN İ. E., KALEMCİ O., YÜCEER N., ATASOY A. M.

JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, vol.58, no.6, pp.508-512, 2015 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 58 Issue: 6
• Publication Date: 2015
• Doi Number: 10.3340/jkns.2015.58.6.508
• Journal Name: JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.508-512
• Kütahya Health Sciences University Affiliated: No

Abstract

Background : Cerebral ischemia is as a result of insufficient cerebral blood flow for cerebral metabolic functions. Resveratrol is a natural phytoalexin that can be extracted from grape's skin and had potent role in treating the cerebral ischemia. Apoptosis, a genetically programmed cellular event which occurs after ischemia and leads to biochemical and morphological changes in cells. There are some useful markers for apoptosis like Bcl-2, bax, and p53. The last reports, researchers verify the apoptosis with early markers like Annexin V.