Neuroprotective Effect of Resveratrol on Acute Brain Ischemia Reperfusion Injury by Measuring Annexin V, p53, Bcl-2 Levels in Rats


KIZMAZOĞLU C., AYDIN H. E. , SEVİN İ. E. , KALEMCİ O., YÜCEER N., ATASOY A. M.

JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, cilt.58, ss.508-512, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 58 Konu: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3340/jkns.2015.58.6.508
  • Dergi Adı: JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
  • Sayfa Sayıları: ss.508-512

Özet

Background : Cerebral ischemia is as a result of insufficient cerebral blood flow for cerebral metabolic functions. Resveratrol is a natural phytoalexin that can be extracted from grape's skin and had potent role in treating the cerebral ischemia. Apoptosis, a genetically programmed cellular event which occurs after ischemia and leads to biochemical and morphological changes in cells. There are some useful markers for apoptosis like Bcl-2, bax, and p53. The last reports, researchers verify the apoptosis with early markers like Annexin V.