Neuroprotective Effect of Resveratrol on Acute Brain Ischemia Reperfusion Injury by Measuring Annexin V, p53, Bcl-2 Levels in Rats


KIZMAZOĞLU C., AYDIN H. E. , SEVİN İ. E. , KALEMCİ O., YÜCEER N., ATASOY A. M.

JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, vol.58, no.6, pp.508-512, 2015 (SCI-Expanded) identifier identifier identifier

Abstract

Background : Cerebral ischemia is as a result of insufficient cerebral blood flow for cerebral metabolic functions. Resveratrol is a natural phytoalexin that can be extracted from grape's skin and had potent role in treating the cerebral ischemia. Apoptosis, a genetically programmed cellular event which occurs after ischemia and leads to biochemical and morphological changes in cells. There are some useful markers for apoptosis like Bcl-2, bax, and p53. The last reports, researchers verify the apoptosis with early markers like Annexin V.