Antimicrobial Susceptibility and Uropathogens Isolated From Children and Adults with Community-Acquired Urinary Tract Infections

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Yildirim M., Sahin I., Gulcan A., Ozdemir D., Kucukbayrak A., Uzun H., ...More

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.30, no.2, pp.533-538, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 2
  • Publication Date: 2010
  • Doi Number: 10.5336/medsci.2008-9024
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.533-538
  • Kütahya Health Sciences University Affiliated: No


Objective: The aim of this study was to determine the distribution of uropathogens causing community-acquired urinary tract infections in Duzce, and their antimicrobial susceptibility patterns. Material and Methods: The study was conducted prospectively in the Duzce University Medical Faculty between July 2004-June 2006 and included outpatients. Identification of microbial growth and determination of antimicrobial susceptibility by the Kirby-Bauer disk diffusion technique were performed according to the Clinical and Laboratory Standards Institute. Results: In total, 702 bacterial isolates were examined in the study. E. coli (64.1%) was the most common urinary pathogen identified. Klebsiella spp. (9.0%), Proteus spp. (5.8%), Staphylococcus aureus (4.7%), Enterococcus spp. (4.3%), coagulase-negative Staphylococci (2.6%), S. agalactiae (2.1%) and P. aeruginosa (1.9%) were the next most common species isolated. Community acquired uropathogens isolated in our region were highly resistant to trimethoprim/sulfamethoxazole, amoxicillin and amoxicillin clavulanate. However, ciprofloxacin was active against pathogens examined in this study with susceptibilities between 64.7% and 88.8% for the most prevalent pathogens (E. coli, 81.0% susceptible). The susceptibility of gram-negative pathogens to the parenterall antibiotics seemed to be higher than the oral agents. Conclusion: Many oral antimicrobial agents do not seem to be appropriate for the empirical treatment of community-acquired urinary tract infections in our region due to very high rates of resistance. Some oral antibiotics such as ciprofloxacin and cefaclor should be used cautiously in adults.