Comparison of the Different PCOS Phenotypes Based on Monocyte to HDL Cholesterol Ratio

Soysal C., Bıyık İ., İnce O., Erten Ö., Taşçı Y., Keskin N.

Journal Of Obstetrics And Gynaecology, vol.12, pp.1-8, 2022 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 12
  • Publication Date: 2022
  • Journal Name: Journal Of Obstetrics And Gynaecology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1-8
  • Kütahya Health Sciences University Affiliated: Yes


In this study, we aimed to evaluate the degree of inflammation in PCOS phenotypes by comparing the monocyte-to-HDL ratios showing inflammatory and oxidative stress among different phenotypes of PCOS. In this case-control study, we studied 186 women with PCOS and 59 age-matched healthy women. PCOS women were prospectively classified into four phenotypes based on NIH Expert Panel criteria. The degree of inflammation between the non-PCOS control group and four PCOS phenotypes was compared by measuring MHR. The prevalence of phenotypes A, B, C and D were 29%, 22%, 26%, and 23%, respectively. MHR was found to be the highest in phenotype A (13.7 ± 4.9) among the PCOS phenotypes and the lowest level was found in phenotype D (9.0 ± 1.9), which is the non-androgenic phenotype. MHR were significantly different across the four PCOS phenotypes; with the highest value were present with phenotype A.  As an easily accessible simple marker, the monocyte / HDL ratio may be promising for detecting at-risk metabolic phenotypes in PCOS.