Journal Of Obstetrics And Gynaecology, vol.12, pp.1-8, 2022 (SCI-Expanded)
In this study, we aimed to evaluate the degree of inflammation in PCOS phenotypes by comparing the monocyte-to-HDL ratios showing inflammatory and oxidative stress among different phenotypes of PCOS. In this case-control study, we studied 186 women with PCOS and 59 age-matched healthy women. PCOS women were prospectively classified into four phenotypes based on NIH Expert Panel criteria. The degree of inflammation between the non-PCOS control group and four PCOS phenotypes was compared by measuring MHR. The prevalence of phenotypes A, B, C and D were 29%, 22%, 26%, and 23%, respectively. MHR was found to be the highest in phenotype A (13.7 ± 4.9) among the PCOS phenotypes and the lowest level was found in phenotype D (9.0 ± 1.9), which is the non-androgenic phenotype. MHR were significantly different across the four PCOS phenotypes; with the highest value were present with phenotype A. As an easily accessible simple marker, the monocyte / HDL ratio may be promising for detecting at-risk metabolic phenotypes in PCOS.