Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats


Koçak C., Koçak F. E. , Akcılar R. , Işıklar Ö. Ö. , Koçak H. , Bayat Z., ...More

LIFE SCIENCES, vol.147, pp.15-23, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 147
  • Publication Date: 2016
  • Doi Number: 10.1016/j.lfs.2016.01.038
  • Title of Journal : LIFE SCIENCES
  • Page Numbers: pp.15-23
  • Keywords: Carnosic acid, Embelin, Heart, Isoproterenol, Myocardial infarction, Myocardial ischemia, ISCHEMIA-REPERFUSION INJURY, DECREASES CARDIOMYOCYTE APOPTOSIS, CULTURED CARDIAC MYOCYTES, OXIDATIVE STRESS, INDUCED CARDIOTOXICITY, ANTIOXIDANT RESPONSE, BINDING PROTEIN, TROPONIN-I, DAMAGE, HEART

Abstract

Aims: Acute myocardial infarction is a serious acute cardiac disorder and heart disease is still a major public health problem in adults. We investigated the effects of embelin (EMB) and carnosic acid (CA) in animals with isoproterenol (ISO)-induced myocardial injury.