THE COMPARISON OF INSULIN, IGF-I, IGF-II, LEPTIN, ADIPONECTIN, GHRELIN, RESISTIN, AND VISFATIN LEVELS OF UMBLICAL CORD BLOOD BETWEEN PRETERM, TERM SGA, AGA, LGA AND DICHORIONIC TWIN NEWBORN


Yalınbaş E. E. , Seven A. , Şimşek E., Akşit M. A.

12th WORLD CONGRESS PERINATAL MEDICINE, Madrid, İspanya, 3 - 05 Kasım 2015, ss.44

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Madrid
  • Basıldığı Ülke: İspanya
  • Sayfa Sayıları: ss.44

Özet

Recent studies about mechanisms controlling intrauterine growth indicated that white adipose tissue is a highly

active endocrine organ, secreting a range of hormones of importance in modulating metabolism, energy

homeostasis and growth, collectively called adipocytokines. Beside well known potent effects of insulin and IGF

system on fetal growth; adipocytokines are also expressed and secreted by placenta and adipocytes and suggested

to incorporate regulation of fetal growth and speculated to have a role in future development of metabolic and

cardivascular disease including obesity, hypertension, insulin resistance and type II diabetes mellitus. We studied

umblical cord insulin, IGF-I, IGF-II, leptin, adiponectin, ghrelin, resistin and visfatin levels in term SGA, AGA,

LGA, preterm and dichorionic twin newborns, compared levels between groups and correlation analysis was

applied for gestational age, anthropometric measures and for studied parameters. Regression analysis was also

applied. There was no significant difference in insulin levels between groups. IGF-I, IGF-II and leptin levels were

significantly higher in AGA and LGA groups than SGA, preterm and twin groups. LGA group had higher IGF-I

level than AGA group. Adiponectin level was found to be significantly higher in AGA group than preterm group.

In SGA group adiponectin level was similar with AGA and twin groups, higher than preterm group and lower than

LGA group. Adiponectin level in LGA group was also significantly higher than prematur and twin groups. Ghrelin

level in AGA group was higher than twin group. LGA group had significantly higher ghrelin levels than SGA,

preterm and twin groups. Visfatin level in SGA group was significantly higher than AGA and preterm groups and

was similar with LGA and twin groups. In hypogylcemic newborns just insulin was found to be significantly higher

than normoglycemic cases. Birth weight, lenghth, head circumference and ponderal index were all positively

correlated with, IGF-I, IGF-II, leptin, adiponectin and ghrelin. Ponderal index was also weakly positively

correlated with resistin. Regression analysis revealed that IGF-I, leptin and adiponectin affect birth weight. Insulin

was positively correlated with IGF-I, IGF-I was also negatively correlated with resistin. There was positive

correlation between IGF-II, adiponectin and ghrelin. Visfatin and resistin were found to be negatively correlated. It

was concluded that major determinant of fetal glucose metabolism is insulin and fetal growth is regulated primarily

by IGF-I, leptin, adiponectin and complex interaction of IGF-II, ghrelin and other adipocytokines. High visfatin

level in SGA group can be an early prognostic marker of future developing metabolic syndrome.