Research Information System
Biomarkers in Medicine, vol.19, no.15, pp.637-645, 2025 (SCI-Expanded, Scopus)
Aim: Our study aimed to investigate the relationship between oxidized low-density lipoprotein(ox-LDL), lectin-like ox-LDL receptor-1 (LOX-1), inducible nitric oxide synthase(iNOS), endothelin 1(ET-1), and asprosin levels with cardiovascular risk. Method: The study is a case-control study. 177 patients (87 HT/90 controls) were included in the study. Biochemical parameters and blood pressure were measured. Cardiovascular risk was calculated using the European Society of Cardiology Cardiovascular Diseases (ESC CVD) risk calculator. Asprosin, oxLDL, LOX1R, ET1 and iNOS levels were measured using Enzyme-Linked ImmunoSorbent Assay (ELISA) kits in blood samples obtained after a minimum 8-hour fasting period. In statistical analyses, p < 0.05 was considered significant. Results: Age was significantly higher in the patient group than in the control group(p <.001). Following adjustment for confounding variables, including age, sex, BMI and smoking status, ANCOVA analysis revealed that ET-1 [F(1,177) = 4.002, p =.047, ηp2 = 0.133] and oxLDL [F(1,177) = 17.221, p <.001, ηp2 = 0.262] levels were elevated in the control group relative to the HT group. The correlation analysis revealed a positive correlation between age and cardiovascular risk (p <.001). Furthermore, a negative correlation was identified between cardiovascular risk and ET1 (p <.05), iNOS (p <.001), asprosin (p <.05) and oxLDL;(p <.001). Conclusion: ET1 and ox-LDL were lower in the HT group treated with antihypertensive therapy compared to the control group. Moreover, asprosin was found to be low in patients with high cardiovascular risk.