ACUTE TRANSIENT VISUAL LOSS FOLLOWING ANTIHISTAMINE ADMINISTRATION IN A TRAUMA PATIENT WITH GILBERT SYNDROME
13th International Acharaka Congress on Medicine, Nursing, Midwifery, and Health Sciences, 16 - 18 February 2026, pp.946-947, (Full Text)
- Publication Type: Conference Paper / Full Text
- Doi Number: 10.30546/19023.9789952-610-29-1.2025.5093
- Page Numbers: pp.946-947
- Open Archive Collection: AVESIS Open Access Collection
- Kütahya Health Sciences University Affiliated: Yes
Abstract
Background: Gilbert syndrome is a benign hereditary hyperbilirubinemia caused by reduced UDPglucuronosyltransferase activity. Although antihistamines are generally considered safe, altered hepatic
metabolism may predispose susceptible individuals to unexpected adverse effects.
Case Presentation: A 26-year-old male trauma patient developed sudden, complete bilateral vision loss
shortly after intravenous pheniramine maleate administration for an allergic reaction. Neurological
examination and cranial imaging were normal. The visual loss resolved completely within five hours.
During the episode, total bilirubin level was 1.5 mg/dL. The patient was subsequently diagnosed with
Gilbert syndrome.
Conclusion: Even commonly used and generally safe medications may cause serious neurological
adverse events in patients with underlying metabolic susceptibility. Drug-induced causes should be
considered in cases of unexplained acute vision loss.