Relationship of apelin, procalcitonin, and fetuin-A concentrations with carotid intima-media thickness in acromegaly

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TOPSAKAL Ş., AKIN H. F. , TURGUT S., Yaylali G. F. , HEREK D., AYADA C.

ANNALS OF CLINICAL BIOCHEMISTRY, vol.52, no.4, pp.456-461, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1177/0004563214562431
  • Title of Journal : ANNALS OF CLINICAL BIOCHEMISTRY
  • Page Numbers: pp.456-461

Abstract

Background Acromegaly is characterized by excess growth hormone and insulin-like growth factor-1 concentrations. There is conflicting evidence as to whether acromegaly is associated with an increased risk of atherosclerosis. Apelin is an adipose tissue-derived peptide that may be associated with hyperinsulinemia. Fetuin-A is a hepatocyte produced plasma glycoprotein that has an important role as a calcification inhibitor. The aim of this study was to examine apelin, fetuin-A, and procalcitonin concentrations and to assess their relationship with carotid intima medial thickness (cIMT) in subjects with acromegaly.