The Correlation Between Systemic Inflammatory Response And Survival in Patients with Metachronous and Synchronous Liver Metastatic Colorectal Cancer

Alp Posteki E., Turan Erkek E., Posteki G., Erkek A., Aliustaoğlu M.

Eurasian Journal of Medicine and Investigation, vol.4, no.1, pp.17-23, 2020 (Peer-Reviewed Journal)

  • Publication Type: Article / Article
  • Volume: 4 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.14744/ejmi.2019.18112
  • Journal Name: Eurasian Journal of Medicine and Investigation
  • Journal Indexes: Other Indexes
  • Page Numbers: pp.17-23



Objectives: Recent data suggest that a low lymphocyte count in a colorectal tumor is associated with poor prognosis. The NLR has been shown to be an effective prognostic factor for survival in colorectal and ovarian cancer. It has been suggested that the preoperative NLR may be a simple method to identify patients with a poor prognosis of colorectal cancer. The aim of this study was to evaluate the effect of the NLR on survival in patients with colorectal cancer who underwent liver metastasectomy.

Methods: The study included 76 patients who were admitted to the Medical Oncology Outpatient Clinic of Kartal Dr. Lutfi Kırdar Training and Research Hospital, who underwent liver metastasectomy and were followed up for colorectal cancer and whose clinical data and pre-metastasectomy laboratory values could be retrieved. The SPSS 17.0 software package was used in the analysis of the study. The mean, standard deviation, minimum-maximum, median, rate and frequency values were used for the descriptive statistics of the data. The distribution of the variables was assessed by the Kolmogorov Smirnov test. The independent samples t-test and Mann-Whitney U test were used for the analysis of quantitative data. The chi-square test was used for analysis of qualitative data. The Cox regression and Kaplan-Meier survival analysis were used for survival analyses. Spearman’s correlation analysis was used for correlation analyses. Results: Age had a significant effect on survival time in the univariate model (p<0.05). Sex, colonic localization, lymph node involvement, histological grade, metastatic status, surgical margin, diameter of metastases, number of metasta- ses, leukocytes, neutrophils, lymphocytes, NLR, CRP, albumin and CEA parameters had no significant effect on survival in the univariate model (p>0.05).

Conclusion: In our study, when a survival analysis was carried out on all variables, the only variable affecting survival was age. The mean age of the metasynchronous group was 56.2±10.6 years, and the mean age of the synchronous group was 61.3±11.1 years. Despite the numerical difference, there was no statistical significance (p=0.055). Although the mean age of the synchronous group was numerically higher, the survival was longer. This may be due to the short follow-up time and the small sample size.

Keywords: Colorectal cancer, liver metastatis, metasynchronous, neutrophil-lymphocyte ratio

Cite This Article: Posteki EA, Turan Erkek E, Posteki G, Erkek A, Aliustaoglu M. The Correlation Between Systemic Inflammatory Response And Survival in Patients with Metachronous and Synchronous Liver Metastatic Colorectal Cancer. EJMI 2020;4(1):17–23.