Synthesis and pharmacology of some new carbamodithioic acid esters
Arzneimittel-Forschung/Drug Research, vol.42, no.2, pp.123-126, 1992 (Scopus)
- Publication Type: Article / Article
- Volume: 42 Issue: 2
- Publication Date: 1992
- Journal Name: Arzneimittel-Forschung/Drug Research
- Journal Indexes: Scopus
- Page Numbers: pp.123-126
- Keywords: antihistaminics, carbamodithioic acid esters, dithiocarbamates, pharmacology, synthesis
- Kütahya Health Sciences University Affiliated: Yes
Abstract
In this study 13 new dithiocarbamates were prepared by reacting 3-methyl-6-chloroacetyl-benzoxazolinone with potassium N'N-disubstituted dithiocarbamate derivatives. The structures of the compounds were confirmed by CV IR, 1H-NMR, mass spectroscopic methods and elementary analysis. The anticholinergic activity was tested on rabbit ileum. With exception of one compound all derivatives exhibited a stronger antihistaminic activity as compared with their anticholinergic action.