Metabolic Status Assesment in Dental Implant Patients by Lens Autofluorescence: Case Series

Eken Ş., Güler B., Köylüoğlu A. N.

CLINICAL ORAL IMPLANTS RESEARCH, vol.33, no.S 24, pp.164, 2022 (SCI-Expanded)

  • Publication Type: Article / Abstract
  • Volume: 33 Issue: S 24
  • Publication Date: 2022
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.164
  • Kütahya Health Sciences University Affiliated: Yes


EAO-­576­/­PO-­139 | Metabolic­status­assessment­in­dental­ implant­patients­by­lens­autofluorescence:­Case­series

Şeyma Eken1,*; Berceste Güler1; Ayşe Nilüfer Köylüoğlu2 1Department of Periodontology, Kütahya Health SciencesUniversity Faculty of Dentistry; 2Department of Ophthalmology, Kütahya University of HealthSciencesFaculty of Medicine, Kütahya, Turkey

Background: Uncontrolled diabetes mellitus (DM) is a metabolic disease that affects both the osseointegration process and soft and hard tissue stabilization after implant treatment. The primary evaluation criterion for DM and wound healing is the HbA1c value, but this value only provides information on 3-month glucose con- trol. Lens autofluorescence, a new AGE evaluation device, is a new system that provides information about all lifetime AGE evaluations. AGE accumulation is a measure of oxidative stress. Aim­/­Hypothesis: In this case series, information about lens au- tofluorescence value (ClearPath DS-120), HbA1c value, and dental implant wound healing will be presented before and after implant surgery.

Material­and­Methods: Eight patients (6 men, 2 women) with a mean- age of 42.5 (31-55) who applied to our clinic for dental implant treat- ment were evaluated both systemic and dental. For the metabolic status evaluation of all patients before implant surgery, advanced glycation end product (AGE) levels in their body and fasting blood glucose and HbA1c levels were determined by lens autofluorescence screening test (ClearPath DS-120). The patients were divided into 2 groups (Type 1-2) according to the presence of DM, 4 groups (Stage 1-4) according to the 2017 periodontal classification for the severity of periodontitis, and 3 groups (Level 1-3) in terms of fluorescence value. Although the levels determined by the fluorescence value for

the lens autofluorescence test vary depending on age; It is deter- mined as below 50% for Level 1, between 50% and 80% for Level 2, and above 80% for Level 3.

Results: Of the 8 patients included, 6 (75%) had severe periodontitis (Stage 3-4), and 4 (50%) had high fluorescence measurement values (Level 3-4). The HbA1c value of 3(60%) of the 5 diabetic patients was above normoglycemic level (4.5 < HbA1c < 5.7). All 4 patients with high fluorescence values had DM, and 3 (75%) had severe periodon- titis and HbA1c values were above the normoglycemic level. It was observed that diabetes, HbA1c value, and severe periodontal de- struction were associated with high fluorescence values. In addition, one of the patients, who was thought to be systemically healthy, underwent tooth extraction before implant surgery. Fluorescence value was measured by lens autofluorescence test since soft tissue healing was impaired for 3 weeks in the extraction area of the pa- tient with good oral hygiene. As a result of the high fluorescence value (Level 3,fluorescencevalue = 0,24), the internal medicine de- partment was consulted and the patient was diagnosed with predia- betes and thyroiditis

Conclusion­ and­ Clinical­ implications: With the lens autofluores- cence test, the metabolic status of the patients is evaluated by meas- uring the AGE level accumulated in the ocular fluid in the eye lens. Accordingly, the patients can be diagnosed in terms of prediabetes and DM risk. We think that the lens autofluorescence test will be used in the routine diagnosis and treatment procedure in the future to reveal the oral-systemic condition relationship and evaluate the results in terms of oral surgeries.

Disclosure­of­Interest: None declared.