Evaluation of susceptibility patterns and BRO beta-lactamase types among clinical isolates of Moraxella catarrhalis


Esel D. , Ay-Altintop Y., Yagmur G., Gokahmetoglu S., Sumerkan B.

CLINICAL MICROBIOLOGY AND INFECTION, vol.13, no.10, pp.1023-1025, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 10
  • Publication Date: 2007
  • Doi Number: 10.1111/j.1469-0691.2007.01776.x
  • Title of Journal : CLINICAL MICROBIOLOGY AND INFECTION
  • Page Numbers: pp.1023-1025

Abstract

The aims of this study were to detect BRO beta-lactamase types and to evaluate any correlation with the susceptibility patterns of 90 clinical isolates of Moraxella catarrhalis. The overall prevalences of the bro-1 and bro-2 genes were 78% and 12%, respectively. Penicillin G MICs for BRO-1(+) isolates were significantly higher than those for BRO-2(+) isolates. All the isolates were susceptible to amoxycillin-clavulanate, levofloxacin and cefixime. Resistance to clarithromycin, tetracycline and trimethoprim-sulphamethoxazole was 1.1%, 2.2% and 1.1%, respectively. One-step, length-based PCR was an efficient method to screen for BRO beta-lactamase genes.