Nurses' organisational and professional attitudes play an important role in their intent to leave nursing, a serious problem worldwide. The present study aimed to investigate the demographic and work-related characteristics, organisational-professional commitment, and job satisfaction, which are the predictors of nurses' intent to leave their unit, organisation and profession. This cross-sectional descriptive study was conducted with 335 nurses working at a university hospital in Turkey. The multiple regression analysis was used to analyse the study data. While job satisfaction was the more powerful predictor of intent to leave the unit than were the commitment variables, affective commitment to the organisation was the more powerful predictor of intent to leave the organisation, and affective commitment to the profession was the more powerful predictor of intent to leave the profession. Different dimensions of commitment and job satisfaction are the predictors of intent to leave the unit, organisation and profession. The present study provided useful evidence for nurse managers and policy makers.