Investigation of the Possible Protective Effects of Ketamine and Dantrolene on the Hippocampal Apoptosis and Spatial Learning in Rats Exposed to Repeated Electroconvulsive Seizures as a Model of Status Epilepticus

Gursoy, Ibrahim; BARUN, SÜREYYA; Erdem, Remzi; Keskin, ULYA; Kiziltas, Murat; ATİLLA, PERGİN; MÜFTÜOĞLU, SEVDA; YÜCE, DENİZ; Narin, Firat; ERTUNÇ, AHMET; Sara, Yildirim; Canpinar, Hande

doi:10.5137/1019-5149.jtn.27023-19.3

Investigation of the Possible Protective Effects of Ketamine and Dantrolene on the Hippocampal Apoptosis and Spatial Learning in Rats Exposed to Repeated Electroconvulsive Seizures as a Model of Status Epilepticus

Gursoy I. D., BARUN S., Erdem R., Keskin U., Kiziltas M., ATİLLA P., ...More

TURKISH NEUROSURGERY, vol.30, no.6, pp.871-884, 2020 (SCI-Expanded, Scopus, TRDizin)

Publication Type: Article / Article
Volume: 30 Issue: 6
Publication Date: 2020
Doi Number: 10.5137/1019-5149.jtn.27023-19.3
Journal Name: TURKISH NEUROSURGERY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
Page Numbers: pp.871-884
Keywords: Status epilepticus, Electroconvulsive seizure, Ketamine, Dantrolene, Cognition, Rats, METHYL-D-ASPARTATE, CELL-DEATH, ENDOPLASMIC-RETICULUM, RECEPTOR HYPOFUNCTION, SYNAPTIC PLASTICITY, GABAERGIC NEURONS, MEMORY IMPAIRMENT, SELECTIVE LOSS, DENTATE GYRUS, KAINIC ACID
Kütahya Health Sciences University Affiliated: No

Abstract

AIM: To evaluate the possible neuroprotective effects of ketamine and dantrolene on the hippocampal apoptosis and spatial learning in rats exposed to repeated electroconvulsive seizures (ECS) as a model of status epilepticus (SE).