Lymphangiectatic Variant of Low-Grade Malignant Eccrine Spiradenoma

Akgun G. A., Ahmedov A., Parlar A. İ., Metineren M. H., Deger A. N.

Annals of Dermatology, vol.35, no.1, pp.71-74, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.5021/ad.20.226
  • Journal Name: Annals of Dermatology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Page Numbers: pp.71-74
  • Keywords: Lymphangiectatic variant, Malign eccrine spiradenoma, Spiradenocarcinoma
  • Kütahya Health Sciences University Affiliated: Yes


Low-grade malignant eccrine spiradenoma (spiradenocarcinoma) is a rare sweat gland tumor, which usually arises from a pre- existing benign eccrine spiradenoma. This paper presents the case of a 55-year-old male who had a lesion in his right elbow for 10 years. The microscopic examination revealed a well-demarcated, multilobulated tumor in the dermis and subcutis, which presented with many blood-filled vessels and extensive hemorrhage. The tumor was composed of hyperchromatic, round to oval cells with nucleolar prominence, mild to moderate atypia, and increased mitotic index. Additionally, lymphangiectatic appearance was observed in areas with prominent stromal lymphedema. P53 and Ki-67 had high positivity. Surgical excision of the lesion was performed with adequate surgical margins, and the dissected lymph nodes in the axilla were tumor-negative. After 15 months of follow-up, there was no recurrence or distant metastasis.