Effects of ischemic preconditioning protocols on skeletal muscle ischemia-reperfusion injury

KOÇMAN A. E. , ÖZATİK O. , ŞAHİN A., Guney T., KÖSE A. A. , DAĞ İ., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.193, sa.2, ss.942-952, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 193 Konu: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.jss.2014.09.032
  • Sayfa Sayıları: ss.942-952


Background: Ischemic preconditioning (IPC) is described as brief ischemia-reperfusion (I/R) cycles to induce tolerance to subsequent in response to longer I/R insults. Various IPC protocols can be performed in four combinations as follows: at early or late phases and on local or distant organs. Although many experimental studies have been performed on IPC, no consensus has been established on which IPC protocol is most effective. The aims of the present study were as follows: (1) to compare the variables of preconditioning in different combinations (in early versus late phases; local versus remote organ implementations) and (2) to determine the most therapeutic IPC protocol(s).