Erciyes Medical Journal, vol.42, no.4, pp.441-446, 2020 (Peer-Reviewed Journal)
Article / Article
Erciyes Medical Journal
Emerging Sources Citation Index, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
Type-2 diabetes, diabetic nephropathy, PAI gene, rs1799889, PLASMINOGEN-ACTIVATOR INHIBITOR-1, PAI-1-675 4G/5G POLYMORPHISM, ASSOCIATION, TRAITS
Objective: Type 2 diabetes mellitus (T2 DM) represents a complex metabolic disease with genetic heterogeneity and increasing worldwide prevalence. One of the candidate genes associated with T2 DM and diabetic nephropathy (DN) is the plasminogen activator inhibitor-1 (PAI-1) gene. The present research aimed to reveal the polymorphism frequencies of the PAI-1 gene 4G/5G and to investigate the role of this polymorphism in T2 DM and DN development.