Synthesis of some thiazolyl-pyrazoline derivatives and preliminary investigation of their hypotensive activity
European Journal of Medicinal Chemistry, cilt.35, sa.6, ss.635-641, 2000 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 6
- Basım Tarihi: 2000
- Doi Numarası: 10.1016/s0223-5234(00)00152-5
- Dergi Adı: European Journal of Medicinal Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.635-641
- Anahtar Kelimeler: Chalcone, Hypotensive activity, Pyrazoline, Thiazol, Thiazolyl-pyrazoline
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Some 1-(4-arylthiazol-2-yl)-3,5-diaryl-2-pyrazoline derivatives were synthesized by reacting 1-thiocarbamoyl-3,5-diaryl-2-pyrazoline derivatives with phenacetylbromide in ethanol. The structural elucidation of the compounds were performed by IR, 1H-NMR and Mass spectral data and elemental analyses. The hypotensive activities of 13 compounds were evaluated by using the tail-cuff method. All examined compounds showed appreciable hypotensive activities. Clonidine was used as reference substance in the pharmacological evaluation. (C) 2000 Editions scientifiques et medicales Elsevier SAS.