The Relationship Between First-Trimester Aneuploidy Markers and Birth Weight


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Soysal C. , Sari H. , Erten Ö. , Bıyık İ. , İnce O. , Taşçı Y., ...More

Gynecol Obstet Reprod Med., vol.0, no.0, pp.1-6, 2021 (Refereed Journals of Other Institutions)

  • Publication Type: Article / Article
  • Volume: 0 Issue: 0
  • Publication Date: 2021
  • Doi Number: 10.21613/gorm.2021.1215
  • Title of Journal : Gynecol Obstet Reprod Med.
  • Page Numbers: pp.1-6

Abstract

OBJECTIVE: We aimed to determine the relationship between the first-trimester aneuploidy screeningma

and the predicted weight at birth: Small for gestational age and large for gestational age.

STUDY DESIGN: 594 low-risk pregnant women with a singleton pregnancy, who underwent firsttrimester

aneuploidy screening by measuring nuchal translucency, maternal serum free beta-human

chorionic gonadotropin, and pregnancy-associated plasma protein-A were included in the study. Those

weighing above the 3rd percentile and below the 10th percentile were defined as small for gestational

age, and those over the 90th percentile were defined as large for gestational age.

RESULTS: A total of 594 pregnant women were enrolled. The mean maternal age of the studied group

was 28.8±5.5 years. Low maternal serum pregnancy-associated plasma protein-A levels and decreased

nuchal translucency measurements were associated with the small for gestational age newborn (p<0.001

and p=0.001, respectively). There is a significant correlation with large for gestational age for newborns

only with an increase in maternal serum pregnancy-associated plasma protein-A levels (p=0.001). betahuman

chorionic gonadotropin levels were not associated with the birth weight (p=0.735).

CONCLUSION: Maternal serum pregnancy-associated plasma protein-A levels, one of the markers in firsttrimester

aneuploidy screening, can be used in the prediction of small for gestational age and large forges-

tational age However, due to its low correlation, it is not a suitable screening test for clinical practice. pregnant women with a singleton pregnancy, who underwent first-. Low maternal serum pregnancy-associated plasma protein-A levels and decreased

nuchal translucency measurements were associated with the small for gestational age newborn (p<0.001 and p=0.001, respectively). There is a significant correlation with large for gestational age for newborns only with an increase in maternal serum pregnancy-associated plasma protein-A levels (p=0.001). beta-human chorionic gonadotropin levels were not associated with the birth weight (p=0.735). CONCLUSION: Maternal serum pregnancy-associated plasma protein-A levels, one of the markers in first-trimester aneuploidy screening, can be used in the prediction of small for gestational age and large for ges-tational age However, due to its low correlation, it is not a suitable screening test for clinical practice.