Research Information System
GYNECOLOGY OBSTETRICS & REPRODUCTIVE MEDICINE (GORM), vol.27, no.3, pp.207-212, 2021 (Peer-Reviewed Journal)
OBJECTIVE: We aimed to determine the relationship between the first-trimester aneuploidy screeningma
and the predicted weight at birth: Small for gestational age and large for gestational age.
STUDY DESIGN: 594 low-risk pregnant women with a singleton pregnancy, who underwent firsttrimester
aneuploidy screening by measuring nuchal translucency, maternal serum free beta-human
chorionic gonadotropin, and pregnancy-associated plasma protein-A were included in the study. Those
weighing above the 3rd percentile and below the 10th percentile were defined as small for gestational
age, and those over the 90th percentile were defined as large for gestational age.
RESULTS: A total of 594 pregnant women were enrolled. The mean maternal age of the studied group
was 28.8±5.5 years. Low maternal serum pregnancy-associated plasma protein-A levels and decreased
nuchal translucency measurements were associated with the small for gestational age newborn (p<0.001
and p=0.001, respectively). There is a significant correlation with large for gestational age for newborns
only with an increase in maternal serum pregnancy-associated plasma protein-A levels (p=0.001). betahuman
chorionic gonadotropin levels were not associated with the birth weight (p=0.735).
CONCLUSION: Maternal serum pregnancy-associated plasma protein-A levels, one of the markers in firsttrimester
aneuploidy screening, can be used in the prediction of small for gestational age and large forges-
tational age However, due to its low correlation, it is not a suitable screening test for clinical practice. pregnant women with a singleton pregnancy, who underwent first-. Low maternal serum pregnancy-associated plasma protein-A levels and decreased
nuchal translucency measurements were associated with the small for gestational age newborn (p<0.001 and p=0.001, respectively). There is a significant correlation with large for gestational age for newborns only with an increase in maternal serum pregnancy-associated plasma protein-A levels (p=0.001). beta-human chorionic gonadotropin levels were not associated with the birth weight (p=0.735). CONCLUSION: Maternal serum pregnancy-associated plasma protein-A levels, one of the markers in first-trimester aneuploidy screening, can be used in the prediction of small for gestational age and large for ges-tational age However, due to its low correlation, it is not a suitable screening test for clinical practice.