Research Information System
Logopedics Phoniatrics Vocology, 2026 (SCI-Expanded, Scopus)
Aims: Autologous fascia lata (AFL) is a therapeutic option in the management of unilateral vocal fold paralysis (UVFP). However, the effect of platelet-rich plasma (PRP) administered with AFL is unknown. The aim of this study was to investigate the long-term effects of the combination of minced AFL and PRP in the treatment of UVFP. Methods: Between January 2015 and January 2021, a retrospective evaluation was made of 14 participants diagnosed with UVFP treated with minced AFL+PRP injection. Pre-treatment and postoperative 1-year evaluations were performed with videolaryngostroboscopy, the GRBAS scale, Turkish Voice Handicap Index (T-VHI-10), maximum phonation time (MPT), and acoustic analysis (%Jitter, %Shimmer, fundamental frequency (fo)). Findings: Half of the participants were males, with with a mean age of 42.0 ± 12.1 years. One-year post-intervention, the T-VHI-10 scores decreased significantly (32.1 to 13.8; p = 0.001), mean MPT increased significantly (from 6.57 s to 16.14 s; p = 0.001), and significant improvements were observed in %Jitter (0.8 to 0.3; p = 0.030) and %Shimmer (5.18 to 2.16; p = 0.001) values. No postoperative complications or donor site morbidity were reported in any participant. Conclusions: Combining PRP with minced AFL is a safe, long-acting option for treating UVFP with significant improvement in voice quality. The regenerative effects of PRP may contribute to permanent vocal improvement by increasing fascia fertility. This method can be considered a less invasive alternative to thyroplasty and may provide additional advantages in terms of the use of autologous material and permanence.