3-ACETYL-4-ARYL-5-OXO-2,7,7-TRIMETHYL-1,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AND THEIR CALCIUM ANTAGONISTIC ACTIVITIES


SAFAK C., OZKANLI F., EROL K., AKTAN Y.

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, ss.1154-1156, 1995 (SCI İndekslerine Giren Dergi)

  • Basım Tarihi: 1995
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH
  • Sayfa Sayısı: ss.1154-1156

Özet

Thirteen 3-acetyl-4-aryl-5-oxo-2,7,7-trimethyl-1,4,5,6,7,8-hexahydroquinoline derivatives (5a-m), one of which was synthesized before have been prepared. The structures of the products 5b-m were characterized by IR, H-1-NMR and elemental analyses The calcium antagonistic activity of these compounds was studied in rabbit taenia coli precontracted with I mmol/l Ca+2.