c-Myc Inhibitor 10074-G5 Induces Murine and Human Hematopoietic Stem and Progenitor Cell Expansion and HDR Modulator Rad51 Expression

Aksoz M., Albayrak E., Aslan G. S., Turan R. D., Alyazici L. Y., Siyah P., ...Daha Fazla

CURRENT CANCER DRUG TARGETS, cilt.19, sa.6, ss.479-494, 2019 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1568009618666180905100608
  • Dergi Adı: CURRENT CANCER DRUG TARGETS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.479-494
  • Anahtar Kelimeler: Hematopoietic stem cells, mesenchymal stem cells, small molecules, bone marrow, c-myc, homology-directed repair, ENDOPLASMIC-RETICULUM STRESS, EX-VIVO EXPANSION, METABOLISM, GENE, PROTEIN, RECOMBINATION, KINASE, REPAIR
  • Kütahya Sağlık Bilimleri Üniversitesi Adresli: Hayır

Özet

Background: c-Myc plays a major role in the maintenance of glycolytic metabolism and hematopoietic stem cell (HSC) quiescence.