c-Myc Inhibitor 10074-G5 Induces Murine and Human Hematopoietic Stem and Progenitor Cell Expansion and HDR Modulator Rad51 Expression

Aksoz M., Albayrak E., Aslan G. S., Turan R. D., Alyazici L. Y., Siyah P., ...More

CURRENT CANCER DRUG TARGETS, vol.19, no.6, pp.479-494, 2019 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 19 Issue: 6
  • Publication Date: 2019
  • Doi Number: 10.2174/1568009618666180905100608
  • Journal Name: CURRENT CANCER DRUG TARGETS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.479-494
  • Keywords: Hematopoietic stem cells, mesenchymal stem cells, small molecules, bone marrow, c-myc, homology-directed repair, ENDOPLASMIC-RETICULUM STRESS, EX-VIVO EXPANSION, METABOLISM, GENE, PROTEIN, RECOMBINATION, KINASE, REPAIR
  • Kütahya Health Sciences University Affiliated: No

Abstract

Background: c-Myc plays a major role in the maintenance of glycolytic metabolism and hematopoietic stem cell (HSC) quiescence.