Synthesis and antinociceptive activity of (2-benzazolon-3-yl)propionamide derivatives
Archiv der Pharmazie, cilt.334, sa.1, ss.17-20, 2001 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 334 Sayı: 1
- Basım Tarihi: 2001
- Dergi Adı: Archiv der Pharmazie
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.17-20
- Anahtar Kelimeler: (2-Benzothiazolinon-3-yl)propionamide, (2-benzoxazolinon-3-yl)propionamide, 1H-NMR, Ant inociceptive activity
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The syntheses of (2-benzothiazolinon-3-yl)propionamide and (2-benzoxazolinon-3-yl)propionamide derivatives are reported. The structures of these compounds are elucidated by their IR and 1H-NMR spectral data, as well as by elemental analysis. The compounds were tested for antinociceptive activity by hot plate, tail flick, tail clip, and modified Koster tests. Compounds 6b and 7d were found to be the most promising compounds among the substances investigated.