Synthesis and antinociceptive activity of (2-benzazolon-3-yl)propionamide derivatives
Archiv der Pharmazie, vol.334, no.1, pp.17-20, 2001 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 334 Issue: 1
- Publication Date: 2001
- Journal Name: Archiv der Pharmazie
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.17-20
- Keywords: (2-Benzothiazolinon-3-yl)propionamide, (2-benzoxazolinon-3-yl)propionamide, 1H-NMR, Ant inociceptive activity
- Kütahya Health Sciences University Affiliated: Yes
Abstract
The syntheses of (2-benzothiazolinon-3-yl)propionamide and (2-benzoxazolinon-3-yl)propionamide derivatives are reported. The structures of these compounds are elucidated by their IR and 1H-NMR spectral data, as well as by elemental analysis. The compounds were tested for antinociceptive activity by hot plate, tail flick, tail clip, and modified Koster tests. Compounds 6b and 7d were found to be the most promising compounds among the substances investigated.