AIM: Due to the complex morphology of root canals, detailed clinical evaluation and accurate interpretation of radiographic images are very important. The aim of this case report is to demonstrate the endodontic treatment approaches of 2 different teeth with anatomical variations. CASE REPORT: Case 1; A 44-year-old female patient applied to our clinic with the complaint of severe pain. In the clinical examination of the patient, deep dentin caries was observed in the right mandibular second molar tooth. In the radiographic examination, it was determined that the root canals of the tooth showed anatomical variation, and “C canal” anatomy was detected in the CBCT image. Chemomechanical preparation of the tooth was completed in the first session. Calcium hydroxide was used as an intracanal medicament between sessions for 2 weeks. In the second session, the patient’s complaints were completely resolved, root canal treatment and coronal restoration were completed. Case 2; A 24-year-old male patient was admitted to our clinic with severe pain. In the clinical examination of the patient, deep dentin caries was detected in the right lower second premolar tooth. In the radiographic examination, it was observed that the root canal is separated into two in the middle third portion of the root. In the first session, the chemomechanical preparation of the tooth was completed. Between sessions, calcium hydroxide was administered as an intracanal medicament for 2 weeks. In the second session, the patient’s complaints were completely resolved, root canal treatment and coronal restoration were completed. CONCLUSION: With the correct diagnosis and effective treatment in teeth with anatomically different morphologies, existing teeth could be preserved and successful clinical results could be obtained. Keywords: C-shaped root canal system; Morphology; Root Canal Treatment; Variations; 3 Dimension Imaging