Peripheral vascular endothelial function in essential hyperhidrosis

Esen A. M., Barutcu I., Karaca S., Kaya D., Kulac M., Esen O., ...More

Circulation Journal, vol.69, no.6, pp.707-710, 2005 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 6
  • Publication Date: 2005
  • Doi Number: 10.1253/circj.69.707
  • Journal Name: Circulation Journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.707-710
  • Keywords: Cardiac autonomic regulation, Endothelial function, Essential hyperhidrosis
  • Kütahya Health Sciences University Affiliated: No


Background: Essential hyperhidrosis, a disorder of the eccrine sweat glands, is associated with sympathetic overactivity and the aim of the present study was to determine endothelium-dependent vasodilator function in patients with this condition. Methods and Results: Using high-resolution ultrasound, the diameter of the brachial artery at rest and during reactive hyperemia (flow-mediated dilatation, %FMD endothelial-dependent stimulus to vasodilatation), as well as after sublingual administration of nitroglycerin (%NTG endothelium-independent vasodilatation) was measured in 18 subjects (mean age 27±5 years) with essential hyperhidrosis and 24 healthy control subjects (mean age 29±5 years). Baseline brachial artery diameter and FMD were comparable in both groups (BAD: 4.1 ±0.7 mm vs 4.3±0.5mm (control), p=0.8; FMD: 5.6±1.9% vs 6.7±2.2%, p=0.1). The time-averaged flow velocity during peak reactive hyperemia was similar in the 2 groups (75±11 cm/s vs 72±10cm/s, p=0.5), nor did NTG-induced dilatation in the patients with essential hyperhidrosis differ significantly from that in healthy control subjects (12.8±2.7% vs 14.0±3.6%, p=0.3). Conclusion: These findings suggest that endothelium-dependent dilatation of large conduit arteries is preserved in essential hyperhidrosis and it seems to be a localized disorder of the eccrine sweat glands rather than a generalized disorder involving vascular endothelium.