Activation Syndrome in Patients Diagnosed With Major Depressive Disorder for the First Time
Journal of Nervous and Mental Disease, cilt.Publish Ahead of Print, 2026 (SCI-Expanded, SSCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: Publish Ahead of Print
- Basım Tarihi: 2026
- Doi Numarası: 10.1097/nmd.0000000000001871
- Dergi Adı: Journal of Nervous and Mental Disease
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Abstracts in Social Gerontology, BIOSIS, CINAHL, Educational research abstracts (ERA), EMBASE, MEDLINE, MLA - Modern Language Association Database, Psycinfo
- Anahtar Kelimeler: Activation syndrome, atypical depression, bipolar disorder, hypomania, major depressive disorder, mania
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: – Activation syndrome, a possible consequence of antidepressant treatment, has been linked to suicidal ideation, yet its definition remains debated. This study investigated the frequency and risk factors of activation syndrome in patients with first-episode major depressive disorder. Methods: – Two hundred six patients were assessed at baseline, week 2, and week 4. Baseline measures included the Hypomania-Checklist-32, the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego–autoquestionnaire, and evaluations of anxious distress, mixed features, and atypical depression. Follow-up interviews assessed activation syndrome. Results: – Activation Syndrome occurred in 33% (n = 68). It was associated with younger age, atypical depression, higher Hypomania-Checklist-32 scores, anxious distress, cyclothymic/irritable temperaments, and suicidal ideation. Logistic regression showed past hypomania and atypical depression as significant predictors. Associations remained after excluding mania/hypomania cases. Conclusions: – In first-episode major depressive disorder, past hypomania symptoms and atypical depression increase activation syndrome risk, highlighting the need for close monitoring given implications for bipolarity and suicidality.