Aim: Peripheral nerve injuries are the major health problem in the world. Several neurotrophic agents have been evaluated for their efficacy in nerve injury. We aimed to compare the effects of erythropoietin (EPO), known to have neuroprotective, neuroregenerative and anti-inflammatory properties like gabapentin, on the sciatic nerve in experimental crush injury to the sciatic nerve in rats. Material and Method: We classified four groups for this study. Aneurysm clips were used for the sciatic nerve crush injury for trauma groups. Sciatic nerve and blood samples were taken for the experimental procedures. ELISA method was used to evaluate the tissue. Results: Average values of IL-1 beta and TNF-alpha levels of the groups and the relationship between the groups are presented. After EPO and gabapentin treatment, IL-1 beta levels were significantly lower in the trauma group. TNF-alpha levels were statistically significantly higher in the trauma group than in other groups. According to the EPO and gabapentin treatment, TNF-alpha levels were significantly lower than those in the trauma group. Discussion: In this study, the effects of EPO and gabapentin on the rat sciatic nerve injury were examined by biochemical methods. EPO is a drug that has an advantage of the treatment of anemia and used for the nerve damage in the experimental studies. We suggest that the EPO has beneficial effects on the trauma models with the blood loss and the nerve damage.