Gastroprotective effects of sulforaphane and thymoquinone against acetylsalicylic acid-induced gastric ulcer in rats

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Zeren S., Bayhan Z., Koçak F. E., Koçak C., Akcılar R., Bayat Z., ...More

JOURNAL OF SURGICAL RESEARCH, vol.203, no.2, pp.348-359, 2016 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 203 Issue: 2
• Publication Date: 2016
• Doi Number: 10.1016/j.jss.2016.03.027
• Journal Name: JOURNAL OF SURGICAL RESEARCH
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.348-359
• Keywords: Gastric ulcer, Non-steroidal anti-inflammatory drug, Sulforaphane, Thymoquinone, NF-KAPPA-B, NITRIC-OXIDE SYNTHASE, MUCOSAL INJURY, ASYMMETRIC DIMETHYLARGININE, OXIDATIVE STRESS, HEME OXYGENASE-1, NIGELLA-SATIVA, TNF-ALPHA, MECHANISMS, PROTECTS
• Kütahya Health Sciences University Affiliated: Yes

Abstract

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) commonly cause gastric ulcers (GUs). We investigated the effects of sulforaphane (SF) and thymoquinone (TQ) in rats with acetylsalicylic acid (ASA)-induced GUs.