Gastroprotective effects of sulforaphane and thymoquinone against acetylsalicylic acid-induced gastric ulcer in rats

Zeren S., Bayhan Z., Koçak F. E., Koçak C., Akcılar R., Bayat Z., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.203, sa.2, ss.348-359, 2016 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 203 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.jss.2016.03.027
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.348-359
  • Anahtar Kelimeler: Gastric ulcer, Non-steroidal anti-inflammatory drug, Sulforaphane, Thymoquinone, NF-KAPPA-B, NITRIC-OXIDE SYNTHASE, MUCOSAL INJURY, ASYMMETRIC DIMETHYLARGININE, OXIDATIVE STRESS, HEME OXYGENASE-1, NIGELLA-SATIVA, TNF-ALPHA, MECHANISMS, PROTECTS
  • Kütahya Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) commonly cause gastric ulcers (GUs). We investigated the effects of sulforaphane (SF) and thymoquinone (TQ) in rats with acetylsalicylic acid (ASA)-induced GUs.