Gastroprotective effects of sulforaphane and thymoquinone against acetylsalicylic acid-induced gastric ulcer in rats


Zeren S. , Bayhan Z., Koçak F. E. , Koçak C., Akcılar R. , Bayat Z., ...More

JOURNAL OF SURGICAL RESEARCH, vol.203, no.2, pp.348-359, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 203 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.1016/j.jss.2016.03.027
  • Title of Journal : JOURNAL OF SURGICAL RESEARCH
  • Page Numbers: pp.348-359
  • Keywords: Gastric ulcer, Non-steroidal anti-inflammatory drug, Sulforaphane, Thymoquinone, NF-KAPPA-B, NITRIC-OXIDE SYNTHASE, MUCOSAL INJURY, ASYMMETRIC DIMETHYLARGININE, OXIDATIVE STRESS, HEME OXYGENASE-1, NIGELLA-SATIVA, TNF-ALPHA, MECHANISMS, PROTECTS

Abstract

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) commonly cause gastric ulcers (GUs). We investigated the effects of sulforaphane (SF) and thymoquinone (TQ) in rats with acetylsalicylic acid (ASA)-induced GUs.