Synthesis, antioxidant and antiurease activities of some new 5,6- dichloro-2-(4-fluorobenzyl)-1H-benzimidazole derivatives containing furan, oxadiazole, triazole and thiadiazole moieties


Bektas H., Albay C., MENTEŞE E., Sokmen B. B., Kurt Z., Şen D.

Letters in Drug Design and Discovery, vol.16, no.8, pp.939-947, 2019 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 8
  • Publication Date: 2019
  • Doi Number: 10.2174/1570180815666180827124956
  • Journal Name: Letters in Drug Design and Discovery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.939-947
  • Keywords: 1,2,4-triazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole, Antioxidant, Antiurease, Benzimidazole
  • Kütahya Health Sciences University Affiliated: Yes

Abstract

© 2019 Bentham Science Publishers.Background: Benzimidazoles and its derivatives have been attracting interest for many years because of their biological activities. Benzimidazoles containing different heterocyclic moieties have wide range of biological activities such as antimicrobial, antioxidant, anticancer, antiviral, etc. Methods: In this study, some benzimidazole derivatives containing furan, oxadiazole, triazole and thiadiazole moieties have been synthesized and then evaluated for their antioxidant and antiurease activities. Results: The results showed that all the tested benzimidazoles indicated remarkable urease inhibitory potentials with IC50 values ranging between 0.303±0.03 to 0.591±0.08 µM. Conclusion: In conclusion, synthesized benzimidazole derivatives showed good antioxidant and antiurease activities. Heterocyclic groups on benzimidazole nucleus enhance the activities.