Comparison of serum human Klotho levels and thiol/disulfide homeostasis in women with polycystic ovary syndrome and in healthy women.


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Biyik I. , Erten O. , Isiklar O. O. , Ince O. , Soysal C. , Berikten D. , ...More

Taiwanese journal of obstetrics & gynecology, vol.60, no.3, pp.487-491, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1016/j.tjog.2021.03.017
  • Title of Journal : Taiwanese journal of obstetrics & gynecology
  • Page Numbers: pp.487-491

Abstract

Objectives: Women with polycystic ovary syndrome (PCOS) have an increased cardiometabolic risk.

Similarly, it was previously shown that atherosclerotic and cardiovascular risk is increased in the general

population with lower serum Klotho levels. The aim of this study was to investigate the lotho and thiol/

disulfide levels in women with non-obese PCOS compared to healthy controls and also to investigate the

relationship of serum Klotho and thiol/disulfide homeostasis with cardiometabolic risk factors.

Materials and methods: In this prospective case control study, human serum alpha Klotho levels and

thiol/disulfide homeostasis of women with PCOS aged between 19-33 were compared to their age and

BMI matched non e PCOS healthy controls. In addition, the correlation of these molecules with other

metabolic markers/measurements were also investigated.

Results: Metabolic parameters such as mean waist circumference, lipid accumulation product, visceral

adiposity index, fasting insulin, homeostasis model assessment of insulin resistance and triglyceride

values were higher in the PCOS group (p . 0.038, p . 0.008, p . 0.001, p . 0.001, p . 0.002 and

p . 0.002, respectively) compared to controls. However, mean serum Klotho and native thiol levels

(respectively p < 0.0001 and p . 0.038) were lower compared to controls. Correlation analysis revealed

that serum Klotho levels were negatively correlated with BMI, waist circumference, disulphide/total

thiol, disulphide/native thiol, HOMA-IR and LAP-index.

Conclusions: Findings of decreased serum Klotho and native thiol values of the PCOS group compared to

controls and the negative correlation of serum Klotho levels with metabolic markers supports the idea

that decreased Klotho may be another mechanism by which cardiovascular risk is increased in women

with PCOS.