COVID-19 İLİŞKİLİ BİYOKİMYASAL VE HEMATOLOJİK PARAMETRELER: TEK MERKEZLİ POPÜLASYON İNDEKS ÇALIŞMASI

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Kar F., Yılmaz S., Musmul A., Şentürk H.

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi, vol.8, no.1, pp.54-58, 2022 (Peer-Reviewed Journal)

Abstract

Objective: We aimed to examine the effects of COVID-19 on biochemical and hematological parameters such as liver and kidney function tests, electrolyte levels and inflammatory markers. Methods: The research was carried out on 10269 patients who applied to Eskişehir City Hospital between 01.03.2020 and 01.10.2020 with positive and negative COVID-19 test results. Included patients were diagnosed with COVID-19 by real-time polymerase chain reaction and computed tomography Biochemical parameters were examined in the samples of two groups with positive and negative COVID-19 test results. In addition, hematological parameters were obtained retrospectively. Results: BASO%, EOS#, EOS%, HCT, HGB, LYM#, LYM%, MCHC, MCV, MONO#, MONO%, MPV, NEU#, NEU%, PCT and PLT (p<0.05). There was no statistical difference in BASO# and MCH parameters. BASO%, EOS%, HCT, LYM#, LYM%, MCHC, MONO%, NEU%, PCT and RBC parameters in COVID-19 positive patients were higher than in COVID-19 negative patients. Other parameters were lower in positive patients than in negative patients (p<0.05). There was a statistical difference between the groups in all biochemistry test results except potassium and procalcitonin parameters (p<0.05). ALP, ALT, AST, Direct Bilirubin, Total Bilirubin, BUN, CRP, D-Dimer, Ferritin, GGT, Creatinine, LDH and Troponin data obtained from COVID-19 positive patients were higher than control group. Albumin, Chlorine, Iron, Sodium and total protein levels were lower in positive patients than in negative patients (p<0.05). Conclusion: Biochemical variants found in COVID-19 positive patients that may indicate multi-organ dysfunction. Abnormalities in some biochemical indices, such as liver and kidney function tests, may reflect the severity of the disease to some degree. These comprehensive biochemical and hematological indicators can be used to create indexes and panels, taking into account the clinical management of the disease