The relationship between third-generation TSH receptor antibody positivity and cumulative methimazole dose used until remission in graves' disease


Creative Commons License

Ozçelik S., Celik M., Vural A., Aydin B., GÖZÜ H.

Journal of the College of Physicians and Surgeons Pakistan, vol.31, no.5, pp.517-522, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 5
  • Publication Date: 2021
  • Doi Number: 10.29271/jcpsp.2021.05.517
  • Journal Name: Journal of the College of Physicians and Surgeons Pakistan
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.517-522
  • Keywords: Cumulative, Graves’ disease, Methimazole, TSH receptor antibody
  • Kütahya Health Sciences University Affiliated: No

Abstract

© 2021 College of Physicians and Surgeons Pakistan. All rights reserved.Objective: To determine the relationship between the positivity of third-generation TSH receptor antibody (TRAb) at the time of diagnosis and the cumulative methimazole dose used until remission in patients with Graves’ disease. Study Design: Cross-sectional, descriptive study. Place and Duration of Study: Department of Endocrinology and Metabolic Diseases, University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital, Turkey from 2016 to 2018. Methodology: Newly diagnosed Graves' patients were included in the study. The patients were divided into two groups according to whether they entered remission (n: 21) or not (n: 20), in the 18th month of methimazole treatment. In addition, the patients were further divided into two categories, according to TRAb status at the time of diagnosis as negative (n: 17) or positive (n: 24). The TRAb positivity and the cumulative methimazole dose they used until the month of remission were compared in these groups. Results: The mean time to reach remission in 41 patients was 20.5 ± 3.1 months. TSH receptor antibody positivity rate was 58.5%. When the TRAb positivity of the groups was compared according to the state of having remission in the 18th month of the treatment, the positivity rate in the non-remission group was statistically significantly higher (p = 0.023).The time to go into remission was longer and the cumulative methimazole dose requirement was higher in the TRAb positive group (p <0.001). Conclusion: Graves’ disease patients with positive third-generation TRAb were found to have a lower rate of remission in the 18-month period compared to negative patients.