Research Information System
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.43, no.5, pp.68-70, 2019 (SCI-Expanded)
OBJECTIVES: In this study, we aimed to investigate the effects of diet
and exercise therapy on iris, adiponectin and IL-6 levels in obese subjects.
MATERIALS and METHODS: 37 patients who applied for Eskişehir Private
Fora Physical Therapy and Rehabilitation Center between 01.11.2017-
30.05.2018 were included in the study. Patients were divided into 3 groups
according to body mass index (BMI) and diet and exercise therapy were
applied for 8 weeks. Adiponectin, IL-6 serum levels and irisin plasma
levels were measured by enzyme-linked immunosorbent assay (ELISA)
in Eskisehir Osmangazi University Clinical Biochemistry Laboratory
Anthropometric characteristics of 37 individuals participating in the
study were recorded. All values were evaluated before and after treatment
RESULTS: As a result of 8-week diet and exercise treatment, body weight
decreased by 4%. There was a statistically significant difference between
IL-6 levels and adiponectin levels measured at the beginning of the study
and the values measured at the end of the 8-week diet and exercise treatment
respectively(p<0.05), (p<0.01). However there wasn’t a statistically significant
difference in the measured IL-6 and adiponectin values between the groups
separated according to BMI values (p> 0.05). There wasn’t statistically
significant difference between the beginning of the study and the measured
values of irisin at the end of the 8-week diet and exercise treatment (p> 0.05).
CONCLUSIONS: IL-6 and adiponectin, which play a role in obesity
metabolism, showed statistically significant changes with 8-week diet
and exercise treatment. The irisin, which is thought to increase the level
with exercise, didn’t show a statistically significant change in our study.
Keywords: obesity, irisin, adiponectin, interleukin-6