THE EFFECTS OF DIET AND EXERCISE TREATMENT IN IRISIN, ADIPONECTIN, INTERLEUKIN-6 LEVELS IN OBESES

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.43, ss.68-70, 2019 (SCI Expanded İndekslerine Giren Dergi)

OBJECTIVES: In this study, we aimed to investigate the effects of diet

and exercise therapy on iris, adiponectin and IL-6 levels in obese subjects.

MATERIALS and METHODS: 37 patients who applied for Eskişehir Private

Fora Physical Therapy and Rehabilitation Center between 01.11.2017-

30.05.2018 were included in the study. Patients were divided into 3 groups

according to body mass index (BMI) and diet and exercise therapy were

applied for 8 weeks. Adiponectin, IL-6 serum levels and irisin plasma

levels were measured by enzyme-linked immunosorbent assay (ELISA)

in Eskisehir Osmangazi University Clinical Biochemistry Laboratory

Anthropometric characteristics of 37 individuals participating in the

study were recorded. All values were evaluated before and after treatment

RESULTS: As a result of 8-week diet and exercise treatment, body weight

decreased by 4%. There was a statistically significant difference between

IL-6 levels and adiponectin levels measured at the beginning of the study

and the values measured at the end of the 8-week diet and exercise treatment

respectively(p<0.05), (p<0.01). However there wasn’t a statistically significant

difference in the measured IL-6 and adiponectin values between the groups

separated according to BMI values (p> 0.05). There wasn’t statistically

significant difference between the beginning of the study and the measured

values of irisin at the end of the 8-week diet and exercise treatment (p> 0.05).

CONCLUSIONS: IL-6 and adiponectin, which play a role in obesity

metabolism, showed statistically significant changes with 8-week diet

and exercise treatment. The irisin, which is thought to increase the level

with exercise, didn’t show a statistically significant change in our study.

Keywords: obesity, irisin, adiponectin, interleukin-6