NEUROPROTECTIVE EFFECTS OF BORIC ACID ON BRAIN AGAİNST RENAL ISCHEMIA/REPERFUSION INJURY


Hacıoğlu C., Kar F., Kar E., Kar Y., Şentürk H., Kanbak G.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.43, no.5, pp.49-50, 2018 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 43 Issue: 5
  • Publication Date: 2018
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.49-50
  • Kütahya Health Sciences University Affiliated: No

Abstract

OBJECTIVES: Renal ischemia/reperfusion (I/R) may cause distant tissue damage.

Boric acid (BA) with antioxidant properties is suggested to be a protective agent

against I/R injury. The aim of this study was to investigate the neuroprotective

effects of boric acid on brain against renal I/R induced oxidative damage.

MATERIALS and METHODS: 35 rats were divided into five groups: sham,

I/R, I/R+50mg/kg BA, I/R+100mg/kg BA and I/R+200mg/kg BA. Sham

group was only subjected to surgical stress procedure. In I/R group, left

renal artery was isolated and ischemia was induced for 45 minutes with

atraumatic vascular clamp, then followed by 24-hour reperfusion. In I/

R+BA groups, BA was administered intraperitoneally 10 minutes before

reperfusion, unlike the I/R group. In rat brain tissues MDA levels, GSH

levels, SOD activities and NO levels were measured spectrophotometrically.

RESULTS: Renal I/R caused a significant increase in MDA and NO levels as

compared to the values of the control group (P<0.01), but caused a decrease in GSH

levels and SOD activities.Conversely, rats treated with BA prior to reperfusion

showed a significant reduction in the brain MDA and NO levels as compared to

renal I/R group, on the other hand was an increase in GSH levels and SOD activities.

CONCLUSIONS: This study showed protective effects of BA on brain tissue

against renal I/R injury. BA treatment can decrease lipid peroxidation levels

and increase antioxidant enzymes activities in brain hippocampus of renal I/R

induced rats. Our results indicate that BA is useful for brain function maintaining

in renal I/R induced rats.

Keywords: Renal Ischemia/Reperfusion, Brain, Boric Acid, Oxidative Damage,

Neurodegeneration