Inhalation of formaldehyde and xylene induces apoptotic cell death in the lung tissue

Sandikci M., Seyrek K., Aksit H., Kose H.

Toxicology and Industrial Health, vol.25, no.7, pp.455-461, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 7
  • Publication Date: 2009
  • Doi Number: 10.1177/0748233709106824
  • Journal Name: Toxicology and Industrial Health
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.455-461
  • Keywords: apoptosis, BALT, formaldehyde, lung, xylene
  • Kütahya Health Sciences University Affiliated: No

Abstract

The aim of this study was to determine the localization and number of apoptotic cells in lung tissue and bronchus-associated lymphoid tissue (BALT) of newborns, young, and adult rats exposed to formaldehyde (6 ppm) or technical xylene (300 ppm) for 6 weeks (8 h/day). A total of 27 female Sprague-Dawley rats were used. Apoptotic cells were mainly localized around the bronchus and bronchioles and relatively less frequently on the walls of alveoli and interalveolar septa both in control and experimental groups. In the BALT, reactive cells were localized in the area under the epithelium and distributed homogenously within the lymphoid follicles. The numbers of apoptotic cells in the lung tissue including the BALT were significantly higher in young and adult rats exposed to formaldehyde and xylene than those detected in control groups. © 2009, SAGE Publications. All rights reserved.