In this study, arsenic bioaccumulation in the eye and brain tissues of mirror carp (Cyprinus carpio carpio) after arsenic exposure and various biochemical parameter changes were investigated. The fish, weighing about 50 g, were exposed to 0.5 and 1 mg/l arsenic (NaAsO2) concentrations for a month. Arsenic was found to be accumulated both in brain and eye tissues substantially. The accumulation in the eye tissue was determined to be higher than that in the brain tissue. It was also determined that malondialdehyde (MDA) concentration was increased significantly in the eye and brain tissues exposed to arsenic. However, catalase (CAT), superoxide dismutase (SOD) and glutathione reductase (GR) enzyme activities decreased significantly in the eye and brain tissues. On the other hand, no significant change was observed in glutathione peroxidase (GP-x) and glucose 6 phosphate dehydrogenase (G6PD) enzyme activities and total glutathione (tGSH) levels. Altogether, it was found that the eye tissue was affected more than the brain tissue. Also, it was seen that the increase in arsenic concentration in the habitat and the changes in MDA levels and enzyme activities in the fish tissue were not evenly.