Comparison of treatment plans for patients with high-grade brain tumors using two different treatment planning systems in radiotherapy
Journal of X-ray science and technology, vol.34, no.4, pp.479-488, 2026 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 34 Issue: 4
- Publication Date: 2026
- Doi Number: 10.1177/08953996261444398
- Journal Name: Journal of X-ray science and technology
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Compendex, EMBASE, INSPEC, MEDLINE, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Engineering Source (EBSCO)
- Page Numbers: pp.479-488
- Keywords: high-grade brain tumor, intensity-modulated radiotherapy, treatment planning system
- Kütahya Health Sciences University Affiliated: No
Abstract
OBJECTIVE: To compare treatment plans created using the Eclipse and Prowess treatment planning systems for patients diagnosed with high-grade brain tumors in the left temporal lobe and to evaluate target volume coverage and doses delivered to critical organs using intensity-modulated radiotherapy (IMRT) technique. MATERIALS AND METHODS: This retrospective comparative planning study included 15 patients. Plans were created on CT images using step-and-shoot IMRT with 6 MV photons. Eclipse used the Pencil Beam Convolution (PBC) algorithm, while Prowess used the Collapsed Cone Convolution (CCCS) algorithm. A total dose of 60 Gy in 30 fractions was prescribed. Dosimetric parameters were analyzed statistically. RESULTS: Both TPSs achieved comparable target coverage, with no significant differences in conformity and homogeneity indices (p = 0.075 and p = 0.590, respectively) or dose-volume parameters (D95, D98, D2; p > 0.05). Eclipse provided significantly lower doses to the ipsilateral lens, brainstem, left optic nerve, cochlea, and whole brain V40 (p < 0.05). CONCLUSION: Both TPSs demonstrated adequate target coverage; however, Eclipse achieved statistically significant dose reductions in several critical structures, which may have clinical relevance in reducing toxicity risk.