Effects of hydrogen sulfide on acetaminophen-induced acute renal toxicity in rats


Ozatik F. Y. , Teksen Y. , Kadioglu E. , Ozatik O. , Bayat Z.

INTERNATIONAL UROLOGY AND NEPHROLOGY, vol.51, no.4, pp.745-754, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 4
  • Publication Date: 2019
  • Doi Number: 10.1007/s11255-018-2053-0
  • Title of Journal : INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Page Numbers: pp.745-754
  • Keywords: Acetaminophen, Rats, Acute renal injury, H2S, NaHS, ISCHEMIA-REPERFUSION INJURY, INDUCED NEPHROTOXICITY, N-ACETYLCYSTEINE, NITRIC-OXIDE, KIDNEY, ISCHEMIA/REPERFUSION, PROTECTION, MECHANISM, DAMAGE

Abstract

Introduction and aim Hydrogen sulfide (H2S) is an endogenously produced gas-structure mediator. It is proposed to have antioxidant, anti-inflammatory and antiapoptotic effects. Acetaminophen (N-acetyl-P-aminophenol; APAP) is an antipyretic and analgesic medication known as paracetamol. When taken at therapeutic doses there are few side-effects, but at high doses APAP can cause clear liver and kidney damage in humans and experimental animals. In this study, the effects of the H2S donor of sodium hydrosulfide (NaHS) on acute renal toxicity induced by APAP in rats were researched in comparison with N-acetyl cysteine (NAC).