Research Information System
Euroretina 2022, Hamburg, Germany, 1 - 04 September 2022, pp.1, (Summary Text)
Intravitreal Silicone Oil Bubbles After Intravitreal Bevacizumab Injection
Author: Saadet
Gültekin Irgat
Co-authors: Alpaslan
Koc, Emine cakar, Fatih Ozcura
Abstract
Intravitreal Silicone Oil Bubbles After Intravitreal Bevacizumab Injection
Purpose: To present the developing intravitreal silicone oil bubles at the
third dose of intravitreal bevacizumab (avastin) therapy for neovascular
age-related macular degeneration.
Case Report: The case report with fundus photography and biomicroscope
examination.
Results: Intravitreal bevacizumab treatment was planned for a 75-year-old
female patient with the diagnosis of neovascular age-related macular
degeneration. The patient's visual level before treatment was 0.05 (snellen),
intraocular pressure was 14 mm Hg, and central macular thickness was 527
microns. Bevacizumab was prepared under operating room conditions by injecting
a single dose of 1.25 mg/0.05 ml into 30-gauge insulin syringes 30 minutes
before the procedure. Although the patient did not have any complaints after
the first two doses, two days after the third dose injection, the patient
applied to our clinic in panic because of decreased vision and flying objects
in his eye. On examination, the patient's vision was 0.05. Numerous droplets of
silicone oil were observed in the vitreous in dilated funsus examination
(Figure 1). Although the patient's complaints decreased in the first month
follow-up, they continued. There was no decrease in the amount of silicone
droplets in the fundus examination (Figure 2). The source is thought to be
polydimethylsiloxane, a lubricant used to reduce friction between the syringe
barrel and the plunger and allow the plunger to move smoothly within the
chamber. Toxic reactions such as high intraocular pressure and corneal edema
due to silicone oil droplets were not observed in this process.
Conclusion: Silicone oil droplets may occur in the vitreous cavity after
intravitreal drug injections. The likely source of silicone oil is the needles
and syringes used for the injections. Silicone droplets should be kept in mind
in patients presenting with the complaint of floater after intravitreal
injection.
Key Words: intravitreal injection, bevacizumab, silicone oil, floater
Financial Disclosure No have financial relation