Intranasal midazolam for prolonged convulsive seizures
Brain and Development, cilt.22, sa.6, ss.359-361, 2000 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 6
- Basım Tarihi: 2000
- Doi Numarası: 10.1016/s0387-7604(00)00155-8
- Dergi Adı: Brain and Development
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.359-361
- Anahtar Kelimeler: Childhood, Intranasal midazolam, Seizure
- Kütahya Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
In order to determine the efficiency of intranasal midazolam in prolonged convulsive episodes, we conducted a prospective study in children with various types of seizures. Nine patients (six boys, three girls; age range 6 months to 9 years) with prolonged convulsions lasting more than 10 min were treated with intranasal midazolam, 0.3 mg/kg. The success rate was 100% with only one case requiring a second dose. Estimated duration of seizures was 12-30 min (mean 18.6) while mean time elapsed until cessation of seizures was 139.6 s (range 60-480). No significant adverse effects were noted except for one patient who had seizures secondary to serious CNS infection and respiratory depression after intranasal midazolam. (C) 2000 Elsevier Science B.V.