Platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in missed abortion.

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BIYIK İ., albayrak m., keskin f.

Revista Brasileira de Ginecologia e Obstetrícia, vol.42, no.5, pp.235-239, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.1055/s-0040-1709693.
  • Journal Name: Revista Brasileira de Ginecologia e Obstetrícia
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.235-239
  • Keywords: missed abortion, platelet to lymphocyte ratio, neutrophil to lymphocyte ratio, inflammation, SYSTEMIC INFLAMMATORY RESPONSE, MATERNAL SERUM-LEVELS, OXIDATIVE STRESS, PREGNANCY, VOLUME, PREECLAMPSIA, MARKER, RISK
  • Kütahya Health Sciences University Affiliated: Yes


Objective Missed abortion occurs in  15% of all clinical pregnancies. The pathogenesis

is not clearly known. However, defective placentation resulting in maternal

systemic inflammatory response is considered responsible formissed abortion. Platelet

lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) are increasingly cited

parameters of inflammation in the literature. However, no study evaluated the PLR and

NLR rates in missed abortions so far. The aim of the present study is to investigate

whether complete blood count (CBC) inflammatory parameters such as NLR and PLR

are increased in patients with missed abortion.

Methods Medical records of 40 pregnant women whose gestation ended in missed

abortion at between 6 and14 weeks of gestation and of 40 healthy pregnant women

were collected and compared retrospectively. The groups were compared regarding

hemoglobin, hematocrit, platelet count (PLT), mean platelet volume (MPV), platelet

distribution width (PDW), PLR and NLR.

Results Platelet distribution width, NLR and PLR values were higher in the missed

abortion group compared with the healthy pregnant women group (rates are

p . 0.043; p . 0.038; and p . 0.010, respectively). Hematocrit, MPV, and lymphocyte

values were found to be lower in the missed abortion group compared with the healthy

pregnant women group (p . 0.027, p . 0.044 and p . 0.025, respectively).

Conclusion The PDW, NLR and PLR values of the missed abortion group were

reported high; and MPV values were reported low in the present study. These findings

may help to speculate a defective placentation in the pathogenesis of missed abortion.