Objective Missed abortion occurs in 15% of all clinical pregnancies. The pathogenesis
is not clearly known. However, defective placentation resulting in maternal
systemic inflammatory response is considered responsible formissed abortion. Platelet
lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) are increasingly cited
parameters of inflammation in the literature. However, no study evaluated the PLR and
NLR rates in missed abortions so far. The aim of the present study is to investigate
whether complete blood count (CBC) inflammatory parameters such as NLR and PLR
are increased in patients with missed abortion.
Methods Medical records of 40 pregnant women whose gestation ended in missed
abortion at between 6 and14 weeks of gestation and of 40 healthy pregnant women
were collected and compared retrospectively. The groups were compared regarding
hemoglobin, hematocrit, platelet count (PLT), mean platelet volume (MPV), platelet
distribution width (PDW), PLR and NLR.
Results Platelet distribution width, NLR and PLR values were higher in the missed
abortion group compared with the healthy pregnant women group (rates are
p . 0.043; p . 0.038; and p . 0.010, respectively). Hematocrit, MPV, and lymphocyte
values were found to be lower in the missed abortion group compared with the healthy
pregnant women group (p . 0.027, p . 0.044 and p . 0.025, respectively).
Conclusion The PDW, NLR and PLR values of the missed abortion group were
reported high; and MPV values were reported low in the present study. These findings
may help to speculate a defective placentation in the pathogenesis of missed abortion.