The effect of nesfatin-1 on heart L-type Ca2+ channel alpha 1c subunit in rats subjected to chronic restraint stress


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AYADA C. , TURGUT G., TURGUT S.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.116, ss.326-329, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 116 Konu: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.4149/bll_2015_061
  • Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Sayfa Sayısı: ss.326-329

Özet

Background: Elevated L-type Ca2+ channel expression level increases Ca2+ influx. This can cause hypertrophy and pathological remodeling of the heart especially under stress conditions. Nesfatin-1 can activate hypothalamic L, P and Q type Ca2+ channels and increase insulin secretion in pancreatic islet beta cells via activation of L-type Ca2+ channels. On the other hand, the effect of nesfatin-1 on cardiac L-type Ca2+ channels has not been studied yet.