The effects of N-acetylcysteine on experimentally created L-asparaginase-induced liver and pancreatic damage in rats


Yurttas G. N. , ÖZDEMİR Z. C. , TANRIKUT C., Kar E. , Kiraz Z. K. , ALATAŞ İ. Ö. , ...More

LEUKEMIA & LYMPHOMA, 2022 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.1080/10428194.2022.2030474
  • Title of Journal : LEUKEMIA & LYMPHOMA
  • Keywords: L-Asparaginase, N- acetylcysteine, liver, pancreas, ACUTE LYMPHOBLASTIC-LEUKEMIA, INDUCED HEPATOTOXICITY, OCTREOTIDE, CHILDREN, EFFICACY, METHOTREXATE, EXPRESSION, GLUTAMINE, TOXICITY, STRESS

Abstract

In this study, oxidative stress marker (malondialdehyde, MDA) and antioxidant enzymes (glutathione (GSH), catalase (CAT)) levels in the liver and pancreas tissue and the histopathological effects of N-acetylcysteine (NAC) were investigated in L-asparaginase (L-ASP) induced liver and pancreatic damage in rats. Forty male albino rats were divided into four groups. The control group was intraperitoneally injected physiological saline (0.02 mL/g); NAC group was injected NAC (200 mg/kg, five days); L-ASP group was injected single-dose L-ASP (10,000U/kg), and LASP + NAC group was injected NAC for five days following single-dose L-ASP (10,000 U/kg). The surgical operation was performed on all animals on the fifth day. There was no difference between the groups regarding tissue MDA, GSH, and CAT levels (p>.05, for all). In the group receiving NAC after L-ASP, there was a significant improvement in the liver and pancreas damage score than the L-ASP group. NAC was effective in reducing organ damage caused by L-ASP.