The effects of N-acetylcysteine on experimentally created L-asparaginase-induced liver and pancreatic damage in rats


Yurttas G. N. , Özdemir Z. C. , Tanrıkut C., Kar E., Kiraz Z. K. , Alataş İ. Ö. , ...More

LEUKEMIA & LYMPHOMA, vol.63, pp.1445-1454, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63
  • Publication Date: 2022
  • Doi Number: 10.1080/10428194.2022.2030474
  • Journal Name: LEUKEMIA & LYMPHOMA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.1445-1454
  • Keywords: L-Asparaginase, N- acetylcysteine, liver, pancreas, ACUTE LYMPHOBLASTIC-LEUKEMIA, INDUCED HEPATOTOXICITY, OCTREOTIDE, CHILDREN, EFFICACY, METHOTREXATE, EXPRESSION, GLUTAMINE, TOXICITY, STRESS
  • Kütahya Health Sciences University Affiliated: Yes

Abstract

In this study, oxidative stress marker (malondialdehyde, MDA) and antioxidant enzymes (glutathione (GSH), catalase (CAT)) levels in the liver and pancreas tissue and the histopathological effects of N-acetylcysteine (NAC) were investigated in L-asparaginase (L-ASP) induced liver and pancreatic damage in rats. Forty male albino rats were divided into four groups. The control group was intraperitoneally injected physiological saline (0.02 mL/g); NAC group was injected NAC (200 mg/kg, five days); L-ASP group was injected single-dose L-ASP (10,000U/kg), and LASP + NAC group was injected NAC for five days following single-dose L-ASP (10,000 U/kg). The surgical operation was performed on all animals on the fifth day. There was no difference between the groups regarding tissue MDA, GSH, and CAT levels (p>.05, for all). In the group receiving NAC after L-ASP, there was a significant improvement in the liver and pancreas damage score than the L-ASP group. NAC was effective in reducing organ damage caused by L-ASP.