Age-related changes in rat prostate tissue; Perspective of protein oxidation

Uzun D., YANAR K., ATUKEREN P., CEBE T., Mengi M., Ozan T., ...Daha Fazla

Aging Male, cilt.18, sa.1, ss.54-59, 2015 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3109/13685538.2014.951921
  • Dergi Adı: Aging Male
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.54-59
  • Anahtar Kelimeler: Aging, Antioxidant capacity, Lipid peroxidation, Prostate, Protein oxidation
  • Kütahya Sağlık Bilimleri Üniversitesi Adresli: Hayır

Özet

Background: Increased systemic oxidative stress is considered as an important risk factor for prostate cancer occurrence; however, the relationship between impaired redox homeostasis of prostate tissue and aging remains unclear. Objective: In our study, we hypothesized that age-related deterioration of redox homeostasis in prostate tissue may be considered as a predisposing factor for prostate cancer occurrence. Methods: Sprague-Dawley rats were divided into two groups as young control (5 months) and naturally aged (24 months). We investigated the levels of oxidant and antioxidant parameters in prostate tissue. Results: Advanced oxidation protein products, protein carbonyl, non-protein thiol and lipid hydroperoxides levels of aged rats were significantly higher than in the young control rats (p<0.01, p<0.05, p<0.001, p<0.05, respectively). Additionally, antioxidant activity of Cu-Zn-superoxide dismutase in elderly group was significantly lower than young controls (p<0.05). Conclusions: We suggest that increased non-protein thiol levels found in aged rats may prevent further dissemination of oxidative protein damage. We also propose that the increased levels of oxidative protein damage markers and decreased Cu-Zn superoxide dismutase activity in aged prostate may be considered as a predisposing factor for prostate cancer. Further studies are warranted to clarify all these oxidative changes as initiation factors for prostate cancer in the association of aging with prostate cancer.