Insulin-like Growth Factor-I Gene and Insulin-like Growth Factor Binding Protein-3 Polymorphism in Patients with Thyroid Dysfunction

KURŞUNLUOĞLU R., TURGUT S., AKIN H. F., BAŞTEMİR M., KAPTANOĞLU B., GENÇ O., ...More

ARCHIVES OF MEDICAL RESEARCH, vol.40, no.1, pp.42-47, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1016/j.arcmed.2008.10.009
  • Journal Name: ARCHIVES OF MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.42-47
  • Kütahya Health Sciences University Affiliated: No

Abstract

Background and Aims. Thyroid hormones have important roles in normal growth and Back skeletal muscle development. IGF-I is one of the most important growth factors and is needed for the proliferation and development of thyroid cells. It stimulates fibroblasts, follicular and endothelia cells in thyroid gland. It has been shown that thyroid hormones play an important role in the regulation of IGF-I and IGFBP-3. In this study we proposed that IGF-I (CA)19 and IGFBP-3-202 A/C gene polymorphism may affect thyroid functions. For this purpose, frequency of IGF-I (CA)(19) and IGFBP-3-202 A/C gene polymorphism in hypo- and hyperthyroid patients and possible role of these polymorphism in thyroid functions were investigated.