Fascin expression in cholesteatoma: correlation with destruction of the ossicular chain and extent of disease


BİNNETOĞLU A., Sari M., Baglam T., Seven E., YUMUŞAKHUYLU A. C. , TOPUZ M. F. , ...More

CLINICAL OTOLARYNGOLOGY, vol.40, no.4, pp.335-340, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1111/coa.12373
  • Title of Journal : CLINICAL OTOLARYNGOLOGY
  • Page Numbers: pp.335-340

Abstract

ObjectiveFascin is an actin-bundling protein found in cell membrane protrusions and increases cell motility. The expression of fascin in epithelial neoplasms has been described only recently. No data are available concerning the role of this protein in invasive cholesteatoma. Thus, we investigated the expression of fascin in cholesteatoma tissue and the relationship between fascin expression and intraoperative evaluation of the destruction of the ossicular chain and extent of disease.