Effects of genetic variations in the genes encoding NOD1 and NOD2 on type 2 diabetes mellitus and insulin resistance


Özbayer C. , Kurt H., Kebapçı M. N. , Güneş H. V. , Çolak E., Değirmenci İ.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, vol.42, pp.98-102, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42
  • Publication Date: 2017
  • Doi Number: 10.1111/jcpt.12482
  • Title of Journal : JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
  • Page Numbers: pp.98-102

Abstract

What is known and objectiveNucleotide-binding oligomerization domain (NOD) 1 and NOD 2 are members of the NOD-like receptor (NLR) family and contain a caspase recruitment domain. NLRs are located in the cytosol, bind bacterial and viral ligands and play a key role in the realization of innate and adaptive immune response, inflammation, apoptosis and reactive oxygen species generation. Insulin resistance (IR) is a leading cause of type 2 diabetes mellitus (T2DM) and associated with obesity, inflammation and pro-inflammatory responses. NOD1 and NOD2 gene variants may affect the risk of chronic inflammation, insulin resistance and T2DM by shifting the balance between pro- and anti-inflammatory cytokines. The aim of our study was to determine whether the NOD1/2 gene variants might contribute to the risk of T2DM and IR.