Cytotoxic, anti-proliferative and apoptotic effects of noscapine on human estrogen receptor positive (MCF-7) and negative (MDA-MB-231) breast cancer cell lines

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Kocak C., Kocak F. E., Ozturk B., Tekin G., Vatansev H.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.121, pp.43-50, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 121
  • Publication Date: 2020
  • Doi Number: 10.4149/bll_2020_007
  • Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.43-50
  • Keywords: breast neoplasms, docetaxel, immunohistochemistry, MCF-7 cells, noscapine, tamoxifen, POSTMENOPAUSAL WOMEN, MICROTUBULE DYNAMICS, ANTICANCER ACTIVITY, PERTURB MITOSIS, ANALOGS, ARREST
  • Kütahya Health Sciences University Affiliated: Yes

Abstract

AIM: Noscapine, a naturally occurring alkaloid obtained from opium poppy, is a microtubule-targeting agent. This study is aimed to investigate the effects of noscapine on human breast cancer cell lines by comparing them with those of tamoxifen and docetaxel.