Effects of Interactions among Gene Polymorphisms of the Renin-Angiotensin-Aldosterone System on Hypertension in Turkish People from Southeast Anatolia


Arpaci A., Urhan-Kucuk M., Bayramoglu A. , GÜLER H. İ. , Ecevit H., Suner A., ...More

REVISTA ROMANA DE MEDICINA DE LABORATOR, vol.27, no.2, pp.159-168, 2019 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.2478/rrlm-2019-0011
  • Title of Journal : REVISTA ROMANA DE MEDICINA DE LABORATOR
  • Page Numbers: pp.159-168
  • Keywords: hypertension, renin-angiotensin-aldosterone system (RAAS), genetic variations, ACE I/D, haplotype, CONVERTING-ENZYME GENE, I/D POLYMORPHISM, INSERTION/DELETION POLYMORPHISM, BLOOD-PRESSURE, ASSOCIATION, ACE, FREQUENCY, CHINESE, STROKE, HAN

Abstract

Introduction: Hypertension (HT) is characterized by high blood pressure. The reninangiotensin-aldosterone system (RAAS) plays a crucial role in blood pressure (BP) regulation by maintaining vascular tone and the water-sodium balance. We aimed to investigate whether there is any relation between AGT (M235T), ACE (I/D), and AGTR1 (A1166C) genetic polymorphisms and hypertension among Turkish people from Southeast Anatolia.